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Article

Integration host factor alleviates H-NS silencing of the Salmonella enterica serovar Typhimurium master regulator of SPI1, hilA.

Microbiology (Reading, England) - 1 Sept 2011

Queiroz Mário H, Madrid Cristina, Paytubi Sònia, Balsalobre Carlos, Juárez Antonio

Abstract excerpt

Coordination of the expression of Salmonella enterica invasion genes on Salmonella pathogenicity island 1 (SPI1) depends on a complex circuit involving several regulators that converge on expression of the hilA gene, which encodes a transcriptional activator (HilA) that modulates expression of the SPI1 virulence genes. Two of the global regulators that influence hilA expression are the nucleoid-associated...

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Identifiers

PMID: 21680637
DOI: 10.1099/mic.0.049197-0

Genes

SPI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Integration host factor alleviates H-NS silencing of the Salmonella enterica serovar Typhimurium master regulator of SPI1, hilA.PMID 21680637Read ↗

The small nucleoid-binding proteins H-NS, HU, and Fis affect hilA expression in Salmonella enterica serovar Typhimurium.Semantic proximity Read ↗

Hha is a negative modulator of transcription of hilA, the Salmonella enterica serovar Typhimurium invasion gene transcriptional activator.Semantic proximity Read ↗

Long-Distance Effects of H-NS Binding in the Control of hilD Expression in the Salmonella SPI1 LocusSemantic proximity Read ↗

Silencing by H-NS potentiated the evolution of Salmonella.Semantic proximity Read ↗

Bacterial chromatin remodeling associated with transcription-induced domains at pathogenicity IslandsSemantic proximity Read ↗

HilE Interacts with HilD and Negatively Regulates hilA Transcription and Expression of the Salmonella enterica Serovar Typhimurium Invasive PhenotypeSemantic proximity Read ↗

Pervasive transcription enhances the accessibility of H-NS-silenced promoters and generates bistability in <i>Salmonella</i> virulence gene expressionSemantic proximity Read ↗

The HilA Box and Sequences outside It Determine the Magnitude of HilA-Dependent Activation of P prgH from Salmonella Pathogenicity Island 1Semantic proximity Read ↗

Two AraC/XylS family members can independently counteract the effect of repressing sequences upstream of the hilA promoter.Semantic proximity Read ↗

Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation.Semantic proximity Read ↗

Delineation of the Salmonella enterica serovar Typhimurium HilA regulon through genome-wide location and transcript analysis.Semantic proximity Read ↗

Mutations influencing expression of the Salmonella enterica serovar Enteritidis pathogenicity island I key regulator hilA.Semantic proximity Read ↗

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