The HilA Box and Sequences outside It Determine the Magnitude of HilA-Dependent Activation of P prgH from Salmonella Pathogenicity Island 1

Abstract excerpt

Salmonella requires genes on the Salmonella pathogenicity island 1 (SPI1) for the intestinal phase of infection in several models of pathogenesis. In Salmonella enterica serovar Typhimurium, most SPI1 genes are arranged in operons that are coordinately regulated by the SPI1-encoded protein HilA. In the past, it has been shown that HilA directly activates two promoters on SPI1, P(invF-1) and P(prgH). P(invF-1)...

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