Article
Mutations influencing expression of the Salmonella enterica serovar Enteritidis pathogenicity island I key regulator hilA.
Antonie van Leeuwenhoek - 1 Oct 2008
Van Immerseel Filip, Eeckhaut Venessa, Boyen Filip, Pasmans Frank, Haesebrouck Freddy, Ducatelle Richard
Abstract excerpt
Invasion in gut epithelial cells, mediated by genes of the Salmonella pathogenicity island I, is a crucial step in the pathogenesis of Salmonella enterica serovar Enteritidis infections. The most important regulator of the invasive process is the hilA gene. In this study, a transposon bank approach was used to identify DNA sequences affecting expression of hilA. Mutants with decreased hilA expression carried...
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