Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin.

doi:10.1371/journal.pone.0020464

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Article

Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin.

PloS one - 1 Jan 2011

Carrai Maura, Steinke Verena, Vodicka Pavel, Pardini Barbara, Rahner Nils, Holinski-Feder Elke, Morak Monika, Schackert Hans K, Görgens Heike, Stemmler Susanne, Betz Beate, Kloor Matthias, Engel Christoph, Büttner Reinhard, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Stein Angelika, Hemminki Kari, Propping Peter, Försti Asta, Canzian Federico, Barale Roberto, Campa Daniele

Abstract excerpt

Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of avoiding and/or eliminating possible threats to the organism. By using a tagging approach in the region of Taste Receptor 2R38 (TAS2R38)...

Topics

Adult
Aged
Case-Control Studies
Colorectal Neoplasms
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

Quality Control

Receptors, G-Protein-Coupled

White People

Taste Receptors, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 21674048
DOI: 10.1371/journal.pone.0020464
PMCID: PMC3107225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21674048-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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