Article
A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer.
BMC medical genetics - 9 Jun 2010
Campa Daniele, Vodicka Pavel, Pardini Barbara, Naccarati Alessio, Carrai Maura, Vodickova Ludmila, Novotny Jan, Hemminki Kari, Försti Asta, Barale Roberto, Canzian Federico
Abstract excerpt
BACKGROUND: Molecular sensing in the gastro-intestinal (GI) tract is responsible for the detection of ingested harmful drugs and toxins, thereby genetic polymorphisms affecting the capability of initiating these responses may be critical for the subsequent efficiency of the gut in eliminating possible threats to the organism. Although these fundamental control systems have been known for long time, the initial...
Topics
- Aged
- Case-Control Studies
- Colorectal Neoplasms
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic