Article
TAS2R38 polymorphisms, Helicobacter pylori infection and susceptibility to gastric cancer and premalignant gastric lesions.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Sept 2022
Giaccherini Matteo, Rizzato Cosmeri, Gentiluomo Manuel, Lupetti Antonella, Flores-Luna Lourdes, Vivas Jorge, Bravo Maria Mercedes, Kasamatsu Elena, Muñoz Nubia, Canzian Federico, Kato Ikuko, Campa Daniele
Abstract excerpt
BACKGROUND: Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (proline, alanine and valine/tasters or alanine, valine and isoleucine/nontasters) and diplotypes are responsible for individual...
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