Article
Analysis of Genetic Polymorphism of Bitter Taste Receptor TAS2R38 and TAS2R46, and Its Relationship with Eating and Drinking Habits in Japanese ToMMo Subjects.
Journal of nutritional science and vitaminology - 1 Jan 2023
Yamaki Michiko, Saito Hiroki, Mimori Takahiro, Suzuki Yoichi, Nagasaki Masao, Suzuki Kichiya, Satoh-Kuriwada Shizuko, Shoji Noriaki, Isono Kunio, Goto Tomoko, Shirakawa Hitoshi, Komai Michio
Abstract excerpt
Human type 2 taste receptor (TAS2R) genes encode bitter-taste receptors that are activated by various bitter ligands. It has been said that TAS2R38 may detect bitter substances and then suppress their intake by controlling gustatory or digestive responses. The major haplotypes of TAS2R38 involve three non-synonymous, closely-linked single-nucleotide polymorphisms (SNPs), leading to three amino acid substitutions...
Topics
- Humans
- East Asian People
- Genotype
- Polymorphism, Single Nucleotide
- Receptors, G-Protein-Coupled
- Taste
- Drinking Behavior
- Diet
- Taste Receptors, Type 2