Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.

doi:10.1371/journal.pone.0027745

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Article

Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark.

PloS one - 1 Jan 2011

Genick Ulrich K, Kutalik Zoltán, Ledda Mirko, Destito Maria C Souza, Souza Milena M, Cirillo Cintia A, Godinot Nicolas, Martin Nathalie, Morya Edgard, Sameshima Koichi, Bergmann Sven, le Coutre Johannes

Abstract excerpt

Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence. To help optimize the design of future genome-wide-association studies on human taste perception we have used the well-known TAS2R38-PROP association as a tool to determine the...

Topics

Adolescent
Adult
Age Distribution
Benchmarking
Body Mass Index
Female
Genome-Wide Association Study
Genotype
Humans
Linear Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Logistic Models

Male

Middle Aged

Observer Variation

Phenotype

Polymorphism, Single Nucleotide

Propylthiouracil

Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 22132133
DOI: 10.1371/journal.pone.0027745
PMCID: PMC3223210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22132133-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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