Article
Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma.
Gastroenterology - 1 Jan 1991
Tada M, Omata M, Ohto M
Abstract excerpt
Most pancreatic adenocarcinomas are known to have ras gene (oncogene) mutations. The site of the mutations is localized in codon 12 of K-ras gene. Such high incidence and localization of the ras gene mutations have not been observed in any other human malignancies. Polymerase chain reaction and direct sequencing method enabled us to analyze DNA sequence around codon 12 of K-ras gene in small quantities of...
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