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Article

Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma.

Gastroenterology - 1 Jan 1991

Tada M, Omata M, Ohto M

Abstract excerpt

Most pancreatic adenocarcinomas are known to have ras gene (oncogene) mutations. The site of the mutations is localized in codon 12 of K-ras gene. Such high incidence and localization of the ras gene mutations have not been observed in any other human malignancies. Polymerase chain reaction and direct sequencing method enabled us to analyze DNA sequence around codon 12 of K-ras gene in small quantities of...

Topics

Adenocarcinoma
Aged
Autopsy
Base Sequence
Biopsy
DNA, Neoplasm
Genes, ras
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Source

Identifiers

PMID: 1983826
DOI: 10.1016/0016-5085(91)90606-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1983826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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