Article
K-Ras mutations and benign pancreatic disease.
International journal of pancreatology : official journal of the International Association of Pancreatology - 1 Apr 2000
Löhr M, Maisonneuve P, Lowenfels A B
Abstract excerpt
This review addresses the history of the ras oncogene, the techniques used to detect molecular alterations in the ras oncogene, and the application of polymerase chain reaction (PCR)-based methods to determine point mutations in clinical samples of patients with pancreatic diseases, namely pancreatic carcinoma and chronic pancreatitis. The frequency of ras mutations in pancreatic carcinoma is high, ranging from...
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