Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

doi:10.1182/blood-2012-10-461624

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Article

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).

Blood - 6 Jun 2013

Gaidzik Verena I, Schlenk Richard F, Paschka Peter, Stölzle Anja, Späth Daniela, Kuendgen Andrea, von Lilienfeld-Toal Marie, Brugger Wolfram, Derigs Hans Günter, Kremers Stephan, Greil Richard, Raghavachar Aruna, Ringhoffer Mark, Salih Helmut R, Wattad Mohammed, Kirchen Heinz G, Runde Volker, Heil Gerhard, Petzer Andreas L, Girschikofsky Michael, Heuser Michael, Kayser Sabine, Goehring Gudrun, Teleanu Maria-Veronica, Schlegelberger Brigitte, Ganser Arnold, Krauter Jürgen, Bullinger Lars, Döhner Hartmut, Döhner Konstanze

Abstract excerpt

In this study, we evaluated the frequency and prognostic impact of DNMT3A mutations (DNMT3A(mut)) in 1770 younger adult patients with acute myeloid leukemia (AML) in the context of other genetic alterations and the European LeukemiaNet (ELN) classification. DNMT3A(mut) were found in 20.9% of AMLs...

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PMID: 23632886
DOI: 10.1182/blood-2012-10-461624

Genes

ELN
FLT3
IDH1
NPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23632886-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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