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Article

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Physiology (Bethesda, Md.) - 1 May 2015

Saigusa Takamitsu, Bell P Darwin

Abstract excerpt

Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD...

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Identifiers

PMID: 25933820
DOI: 10.1152/physiol.00032.2014
PMCID: PMC4422974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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