Article

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

2021-02-24

Abstract excerpt

Pathophysiological defects in water homeostasis can lead to renal failure. Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder associated with abnormal cytoskeletal dynamics in the kidney collecting ducts and perturbed calcium and cAMP signaling in the ciliary compartment. We show that collecting ducts in mice lacking the A-Kinase anchoring protein AKAP220 exhibit enhanced development...

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Literature Corpus work: a8d16811-e99f-5b80-9add-8f7699c8b230
DOI: 10.1101/2021.02.24.432764

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