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A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

13 Jun 2022

Abstract excerpt

The primary cilium constitutes an organelle that orchestrates signal transduction independently from the cell body. Dysregulation of this intricate molecular architecture leads to severe human diseases, commonly referred to as ciliopathies. However, the molecular underpinnings how ciliary signaling orchestrates a specific cellular output remain elusive. By combining spatially resolved optogenetics with RNA...

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PMID: 35695071
DOI: 10.15252/embr.202154315

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