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Article

Temperature-sensitive poliovirus mutant fails to cleave VP0 and accumulates provirions.

Journal of virology - 1 Sept 1990

Compton S R, Nelsen B, Kirkegaard K

Abstract excerpt

A temperature-sensitive mutant of poliovirus, VP2-103, was isolated and characterized. A single nucleotide change, resulting in the substitution of glutamine for arginine at amino acid 76 of the capsid protein VP2, prevented the maturation of virions at the nonpermissive temperature. Particles indistinguishable from the previously elusive provirions were observed; these particles have been proposed to be...

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Identifiers

PMID: 2166805
DOI: 10.1128/JVI.64.9.4067-4075.1990
PMCID: PMC247868

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Source receipt: pubmed, retrieved 7 Sept 2026.

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