Temperature-sensitive poliovirus mutant fails to cleave VP0 and accumulates provirions.

doi:10.1128/JVI.64.9.4067-4075.1990

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Article

Temperature-sensitive poliovirus mutant fails to cleave VP0 and accumulates provirions.

Journal of virology - 1 Sept 1990

Compton S R, Nelsen B, Kirkegaard K

Abstract excerpt

A temperature-sensitive mutant of poliovirus, VP2-103, was isolated and characterized. A single nucleotide change, resulting in the substitution of glutamine for arginine at amino acid 76 of the capsid protein VP2, prevented the maturation of virions at the nonpermissive temperature. Particles indistinguishable from the previously elusive provirions were observed; these particles have been proposed to be...

Topics

Amino Acid Sequence
Base Sequence
Capsid
Capsid Proteins
Electrophoresis, Gel, Two-Dimensional
HeLa Cells
Humans
Kinetics
Models, Molecular
Molecular Sequence Data
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus

Protein Conformation

Proviruses

RNA, Viral

Temperature

Viral Proteins

Source

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Identifiers

PMID: 2166805
DOI: 10.1128/JVI.64.9.4067-4075.1990
PMCID: PMC247868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2166805-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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