Mutations in VP1 of poliovirus specifically affect both encapsidation and release of viral RNA.

doi:10.1128/JVI.64.1.195-206.1990

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Article

Mutations in VP1 of poliovirus specifically affect both encapsidation and release of viral RNA.

Journal of virology - 1 Jan 1990

Kirkegaard K

Abstract excerpt

The phenotypic defects of two type 1 Mahoney poliovirus mutants, termed VP1-101 and VP1-102, were caused by two different small deletions in the region of the RNA genome encoding the amino terminus of the capsid protein VP1. This portion of VP1 was unresolved in the three-dimensional structure of the poliovirion, buried within the virion, and likely to interact with the viral RNA. Both VP1-101 and VP1-102 showed...

Topics

Animals
Capsid
Capsid Proteins
Cell Line
Chromosome Deletion
Genes, Viral
HeLa Cells
Humans
Kinetics
Models, Structural
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Poliovirus

Protein Conformation

RNA, Viral

Transfection

Viral Plaque Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 2152812
DOI: 10.1128/JVI.64.1.195-206.1990
PMCID: PMC249083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2152812-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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