Article
Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles.
The Journal of general virology - 1 Aug 2013
Boudreaux Crystal E, Vile Donald C, Gilmore Brian L, Tanner Justin R, Kelly Deborah F, McDonald Sarah M
Abstract excerpt
The triple-layered rotavirus virion encases an 11-segmented, dsRNA genome and 11-12 copies of the viral polymerase (VP1). VP1 transcribes and replicates the genome while tethered beneath the VP2 core shell. Genome replication (i.e. minus-strand RNA synthesis) by VP1 occurs in association with core assembly. During this process, VP2 directly engages VP1, thereby (i) packaging the polymerase into a nascent core and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
