Article
Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Aug 2011
Scherer Hans Ulrich, van der Woude Diane, Willemze Annemiek, Trouw Leendert A, Knevel Rachel, Syversen Silje W, van der Linden Michael P M, Lie Benedicte, Huizinga Tom W J, van der Heijde Désirée M F M, van der Helm-van Mil Annette H M, Kvien Tore K, Toes René E M
Abstract excerpt
OBJECTIVES: Human leucocyte antigen shared epitope (SE) alleles are associated with joint destruction, the presence of anticitrullinated protein antibodies (ACPA) and the ACPA fine specificity repertoire in rheumatoid arthritis (RA). A large variation in joint destruction is seen within the ACPA-positive patient population, and it is conceivable that certain ACPA reactivities contribute to radiological damage....
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