Article
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.
Arthritis and rheumatism - 1 Nov 2005
Huizinga Tom W J, Amos Christopher I, van der Helm-van Mil Annette H M, Chen Wei, van Gaalen Floris A, Jawaheer Damini, Schreuder Geziena M T, Wener Mark, Breedveld Ferdinand C, Ahmad Naila, Lum Raymond F, de Vries Rene R P, Gregersen Peter K, Toes Rene E M, Criswell Lindsey A
Abstract excerpt
OBJECTIVE: The main genetic risk factor for rheumatoid arthritis (RA), the HLA region, has been known for 25 years. Previous research has demonstrated, within the RA population, an association between HLA-DRB1 alleles carrying the shared epitope (SE) and antibodies directed against cyclic citrullinated peptides (anti-CCP antibodies). We undertook this study to make the first comparison of SE allele frequencies in...
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