Article
Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.
Annals of the rheumatic diseases - 1 Mar 2008
Karlson E W, Chibnik L B, Cui J, Plenge R M, Glass R J, Maher N E, Parker A, Roubenoff R, Izmailova E, Coblyn J S, Weinblatt M E, Shadick N A
Abstract excerpt
BACKGROUND: HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA). OBJECTIVE: We examined associations between HLA-SE, PTPN22, CTLA4 genotypes and RA phenotypes in a large cohort to (a) replicate prior associations with CCP status, and (b) determine associations with radiographic erosions and age of diagnosis. METHODS: A...
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