Article
Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
Rheumatology (Oxford, England) - 1 Dec 2010
Ohmura Koichiro, Terao Chikashi, Maruya Etsuko, Katayama Masaki, Matoba Kenichiro, Shimada Kota, Murasawa Akira, Honjo Shigeru, Takasugi Kiyoshi, Tohma Shigeto, Matsuo Keitaro, Tajima Kazuo, Yukawa Naoichiro, Kawabata Daisuke, Nojima Takaki, Fujii Takao, Yamada Ryo, Saji Hiroo, Matsuda Fumihiko, Mimori Tsuneyo
Abstract excerpt
OBJECTIVES: ACPA is a highly specific marker for RA. It was recently reported that ACPA can be used to classify RA into two disease subsets, ACPA-positive and ACPA-negative RA. ACPA-positive RA was found to be associated with the HLA-DR shared epitope (SE), but ACPA negative was not. However, the suspicion remained that this result was caused by the ACPA-negative RA subset containing patients with non-RA...
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