Article
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
Arthritis and rheumatism - 1 Dec 2007
Verpoort K N, Cheung K, Ioan-Facsinay A, van der Helm-van Mil A H M, de Vries-Bouwstra J K, Allaart C F, Drijfhout J W, de Vries R R P, Breedveld F C, Huizinga T W J, Pruijn G J M, Toes R E M
Abstract excerpt
OBJECTIVE: In classic studies on the genetic background of antibody production, the major histocompatibility complex (MHC) has been shown to act as the most prominent immune response gene that controls the magnitude and the specificity of antibody production. The strongest genetic risk factor for rheumatoid arthritis (RA), the human MHC HLA-DRB1 shared epitope (SE) alleles, predisposes for antibodies against...
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