The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.

doi:10.4049/jimmunol.1003143

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Article

The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2011

Witzenrath Martin, Pache Florence, Lorenz Daniel, Koppe Uwe, Gutbier Birgitt, Tabeling Christoph, Reppe Katrin, Meixenberger Karolin, Dorhoi Anca, Ma Jiangtao, Holmes Ashleigh, Trendelenburg George, Heimesaat Markus M, Bereswill Stefan, van der Linden Mark, Tschopp Jürg, Mitchell Timothy J, Suttorp Norbert, Opitz Bastian

Abstract excerpt

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the pathogenicity and invasiveness. We tested the hypotheses that the innate immune inflammasome pathway is involved in fighting pneumococcal pneumonia and that some invasive pneumococcal types are not recognized by this pathway. We show that human and murine...

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PMID: 21646297
DOI: 10.4049/jimmunol.1003143

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NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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