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Article

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.

Proceedings of the National Academy of Sciences of the United States of America - 18 Feb 2003

Malley Richard, Henneke Philipp, Morse Sarah C, Cieslewicz Michael J, Lipsitch Marc, Thompson Claudette M, Kurt-Jones Evelyn, Paton James C, Wessels Michael R, Golenbock Douglas T

Abstract excerpt

Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contribute substantially to inflammatory damage, although the interactions between pneumococcal components and host-cell structures have not been elucidated completely. Results of a previous study indicated that cell-wall components of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12569171
DOI: 10.1073/pnas.0435928100
PMCID: PMC149942

Genes

TLR4
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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