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Article

Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniae

15 Jul 2022

Abstract excerpt

Published data for the Streptococcus pneumoniae virulence factor Pneumolysin (Ply) show contradictory effects on the host inflammatory response to infection. Ply has been shown to activate the inflammasome, but also can bind to MRC-1 resulting in suppression of dendritic cell inflammatory responses. We have used an in vitro infection model of human monocyte-derived macrophages (MDM), and a mouse model of...

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PMID: 35835695
DOI: 10.1111/imm.13546

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