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Article

Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection

31 Aug 2021

Abstract excerpt

Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1β signaling plays an important role in GAS disease progression. The host regulates the production and secretion of IL-1β via the cytosolic inflammasome pathway. Activation of the NLR family pyrin domain-containing 3...

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PMID: 34462965
DOI: 10.1111/imcb.12499

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