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Novel Virulence Role of Pneumococcal NanA in Host Inflammation and Cell Death Through the Activation of Inflammasome and the Caspase Pathway

11 Mar 2021

Abstract excerpt

Streptococcus pneumoniaeis one of most deadly Gram-positive bacterium that causes significant mortality and morbidity worldwide. Intense inflammation and cytotoxicity is a hallmark of invasive pneumococcal disease. Pneumococcal NanA has been shown to exaggerate the production of inflammatory cytokines via unmasking of inhibitory Siglec-5 from its sialylcis-ligands. To further investigate the mechanistic role of...

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PMID: 33777832
DOI: 10.3389/fcimb.2021.613195

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