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Article

Pneumolysin: A Double-Edged Sword During the Host-Pathogen Interaction

1 Sept 2008

Abstract excerpt

The cholesterol-dependent cytolysins are pore-forming toxins. Pneumolysin is the cytolysin produced by Streptococcus pneumoniae and is a key virulence factor. The protein contains 471 amino acids and four structural domains. Binding to cholesterol is followed by oligomerization and membrane pore formation. Pneumolysin also activates the classical pathway of complement. Mutational analysis of the toxin and...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 18781957
DOI: 10.2174/156652408785747924

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