Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adiponectin regulation of stellate cell activation via PPARγ-dependent and -independent mechanisms.

The American journal of pathology - 1 Jun 2011

Shafiei Mahnoush S, Shetty Shoba, Scherer Philipp E, Rockey Don C

Abstract excerpt

In this study, we elucidated the mechanism by which adiponectin modulates hepatic stellate cell activation and fibrogenesis. Adiponectin-overexpressing transgenic mice receiving thioacetamide were resistant to fibrosis, compared with controls. In contrast, adiponectin-null animals developed severe fibrosis. Expression of collagen α1(I) and α-smooth muscle actin (α-SMA) mRNAs were significantly lower in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiponectin
Share to Alanine Transaminase
Share to Aspartate Aminotransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Weight

Share to Disease Susceptibility

Share to Hepatic Stellate Cells

Share to Liver Cirrhosis

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 21641391
DOI: 10.1016/j.ajpath.2011.02.035
PMCID: PMC3124230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adiponectin regulation of stellate cell activation via PPARγ-dependent and -independent mechanisms.PMID 21641391Read ↗

Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.Semantic proximity Read ↗

Adipogenic transcriptional regulation of hepatic stellate cells.Semantic proximity Read ↗

Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells.Semantic proximity Read ↗

Hepatic stellate cell–specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosisSemantic proximity Read ↗

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation.Semantic proximity Read ↗

Adipogenic phenotype of hepatic stellate cells.Semantic proximity Read ↗

Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance.Semantic proximity Read ↗

Hepatic stellate cell line modulates lipogenic transcription factors.Semantic proximity Read ↗

Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells.Semantic proximity Read ↗

Resistin mediates the hepatic stellate cell phenotype.Semantic proximity Read ↗

PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.Semantic proximity Read ↗

Morphogens and hepatic stellate cell fate regulation in chronic liver disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.