Article
Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells.
Biochemical and biophysical research communications - 1 Jan 2010
Kim Nayoung, Choi Soyoung, Lim Chaeseung, Lee Hongsik, Oh Junseo
Abstract excerpt
Activation of quiescent hepatic stellate cells (HSCs) into myofibroblast-like cells is a key event of liver fibrosis, and adipogenic transcription factors, PPAR-gamma and C/EBP-alpha, reverse HSC activation. As albumin was reported to maintain the quiescent phenotype of stellate cells, we examined whether it plays a role in PPAR-gamma and C/EBP-alpha-mediated effects. Pancreatic stellate cells (PSCs) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
