Article
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.
Journal of lipid research - 1 Feb 2003
Hellemans Karine, Rombouts Krista, Quartier Erik, Dittié Andrea S, Knorr Andreas, Michalik Liliane, Rogiers Vera, Schuit Frans, Wahli Walter, Geerts Andrea
Abstract excerpt
Activation of cultured hepatic stellate cells correlated with an enhanced expression of proteins involved in uptake and storage of fatty acids (FA translocase CD36, Acyl-CoA synthetase 2) and retinol (cellular retinol binding protein type I, CRBP-I; lecithin:retinol acyltransferases, LRAT). The increased expression of CRBP-I and LRAT during hepatic stellate cells activation, both involved in retinol...
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