Article
Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation.
Journal of gastroenterology and hepatology - 1 Oct 2006
Tsukamoto Hidekazu, She Hongyun, Hazra Saswati, Cheng Jason, Miyahara Takeo
Abstract excerpt
Cirrhosis is the most important consequence of alcoholic liver disease for which liver transplantation is the only treatment option available. Transdifferentiation of hepatic stellate cells (HSC) to myofibroblastic cells (MF) is a central event in liver fibrogenesis, and understanding molecular mechanisms that underlie this cellular event provides pivotal insights into development of new therapeutic modalities...
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