Article
Hepatic stellate cell line modulates lipogenic transcription factors.
Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2007
Guimarães Eduardo L M, Franceschi Mariana F S, Andrade Cláudia M B, Guaragna Regina M, Borojevic Radovan, Margis Rogério, Bernard Elena A, Guma Fátima C R
Abstract excerpt
BACKGROUND/AIMS: Pre-adipocyte differentiation into adipocyte is a terminal differentiation process triggered by a cascade of transcription factors. Conversely, hepatic stellate cells (HSC) can switch between lipid storing and the myofibroblast phenotype in association with liver fibrotic processes. Here, adipogenic/lipogenic-related transcription factors and downstream-regulated genes were evaluated in a murine...
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