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Article

Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility.

Science advances - 1 Sept 2020

Sánchez-Sáez Fernando, Gómez-H Laura, Dunne Orla M, Gallego-Páramo Cristina, Felipe-Medina Natalia, Sánchez-Martín Manuel, Llano Elena, Pendas Alberto M, Davies Owen R

Abstract excerpt

Meiotic reductional division depends on the synaptonemal complex (SC), a supramolecular protein assembly that mediates homologous chromosomes synapsis and promotes crossover formation. The mammalian SC has eight structural components, including SYCE1, the only central element protein with known causative mutations in human infertility. We combine mouse genetics, cellular, and biochemical studies to reveal that...

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Identifiers

PMID: 32917591
DOI: 10.1126/sciadv.abb1660
PMCID: PMC7467691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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