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SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans.

Genetics - 1 Aug 2007

Smolikov Sarit, Eizinger Andreas, Schild-Prufert Kristina, Hurlburt Allison, McDonald Kent, Engebrecht JoAnne, Villeneuve Anne M, Colaiácovo Mónica P

Abstract excerpt

Synaptonemal complex (SC) formation must be regulated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chromosome segregation in meiosis. Here we identify SYP-3, a coiled-coil protein that is required for assembly of the central region of the SC and for restricting its loading to occur only in an appropriate context, forming structures that bridge the axes of paired...

Topics

Animals
Base Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Chromosome Pairing
Chromosome Segregation
DNA Primers
DNA, Helminth
Genes, Helminth
Meiosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Genetic

Mutation

Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 17565948
DOI: 10.1534/genetics.107.072413
PMCID: PMC1950610

Genes

SYP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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