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Alterations in synaptonemal complex coding genes and human infertility

1 Jan 2022

Abstract excerpt

About 10% of reproductive-aged couples suffer from infertility. However, the genetic causes of human infertility cases are largely unknown. Meiosis produces haploid gametes for fertilization and errors in meiosis are associated with human infertility in both males and females. Successful meiosis relies on the assembly of the synaptonemal complex (SC) between paired homologous chromosomes during the meiotic...

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PMID: 35342360
DOI: 10.7150/ijbs.67843

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