Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes.

Developmental biology - 1 Jan 2001

Oe T, Nakajo N, Katsuragi Y, Okazaki K, Sagata N

Abstract excerpt

Chk1, a nuclear DNA damage/replication G2 checkpoint kinase, phosphorylates Cdc25 and causes its nuclear exclusion in yeast and mammalian cells, thereby arresting the cell at the G2 phase until DNA repair/replication is completed. Chk1 is also involved, at least in part, in the natural G2 arrest of immature Xenopus oocytes, but it is unknown how Chk1 inhibits Cdc25 function and undergoes regulation during oocyte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to cdc25 Phosphatases
Share to Cell Compartmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 1

Share to G2 Phase

Share to Tyrosine 3-Monooxygenase

Share to Xenopus

Share to Xenopus Proteins

Source

Identifiers

PMID: 11133168
DOI: 10.1006/dbio.2000.9968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes.PMID 11133168Read ↗

Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes.Semantic proximity Read ↗

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Semantic proximity Read ↗

CHK1-CDC25A-CDK1 regulate cell cycle progression in early mouse embryos to protect genome integritySemantic proximity Read ↗

Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespanSemantic proximity Read ↗

Nuclear Chk1 prevents premature mitotic entry.Semantic proximity Read ↗

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.Semantic proximity Read ↗

CDC6 requirement for spindle formation during maturation of mouse oocytes.Semantic proximity Read ↗

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.Semantic proximity Read ↗

CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3.Semantic proximity Read ↗

Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events.Semantic proximity Read ↗

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation.Semantic proximity Read ↗

Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.