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Article

Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase.

Experimental cell research - 1 Apr 2005

Nakayama Yuji, Yamaguchi Naoto

Abstract excerpt

Chk tyrosine kinase phosphorylates Src-family tyrosine kinases and suppresses their kinase activity. We recently showed that Chk localizes to the nucleus as well as the cytoplasm and inhibits cell proliferation. To investigate the role of nuclear Chk in proliferation, various Chk mutants were constructed and expressed. Nuclear localization of Chk-induced dynamic multi-lobulation of the nucleus and prolonged S...

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Identifiers

PMID: 15748901
DOI: 10.1016/j.yexcr.2004.11.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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