Article
CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3.
EMBO reports - 1 Nov 2024
Zhang Honghui, Cui Ying, Yang Bohan, Hou Zhenzhen, Zhang Mengge, Su Wei, Chen Tailai, Bian Yuehong, Li Mei, Chen Zi-Jiang, Zhao Han, Zhao Shigang, Wu Keliang
Abstract excerpt
CHK1 mutations could cause human zygote arrest at the pronuclei stage, a phenomenon that is not well understood at the molecular level. In this study, we conducted experiments where pre-pronuclei from zygotes with CHK1 mutation were transferred into the cytoplasm of normal enucleated fertilized eggs. This approach rescued the zygote arrest caused by the mutation, resulting in the production of a high-quality...
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