Article
Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Grant S G, Jessee J, Bloom F R, Hanahan D
Abstract excerpt
Plasmids comprising transgene insertions in four lines of transgenic mice have been retrieved by plasmid rescue into a set of Escherichia coli strains with mutations in different members of the methylation-dependent restriction system (MDRS). Statistical analysis of plasmid rescue frequencies has revealed that the MDRS loci detect differential modifications of the transgene insertions among mouse lines that show...
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