Article
A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice.
Mutation research - 17 May 1996
Gondo Y, Shioyama Y, Nakao K, Katsuki M
Abstract excerpt
To positively detect the in vivo mutations accumulated in different mouse organs, we have developed a transgenic mouse system. This transgenic mouse carried an Escherichia coli (E. coli) plasmid pML4 as a shuttle vector that consisted of a replication origin (ori), the kanamycin-resistant gene (K...
Topics
- Animals
- Blotting, Southern
- DNA
- DNA Modification Methylases
- Electroporation
- Escherichia coli
- Escherichia coli Proteins
- Female
- Gene Dosage
- Genetic Markers
- Genetic Vectors
- Liver
- Male
- Methylation
- Methylnitrosourea
- Mice
- Mice, Transgenic
- Mutagens