Article
A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice.
Mutation research - 17 May 1996
Gondo Y, Shioyama Y, Nakao K, Katsuki M
Abstract excerpt
To positively detect the in vivo mutations accumulated in different mouse organs, we have developed a transgenic mouse system. This transgenic mouse carried an Escherichia coli (E. coli) plasmid pML4 as a shuttle vector that consisted of a replication origin (ori), the kanamycin-resistant gene (KanR) and the rpsL+ gene (strAS) derived from E. coli. These E. coli elements were expected to be inert in the...
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