Article
A domain of the insulin receptor required for endocytosis in rat fibroblasts.
The Journal of biological chemistry - 15 Jun 1990
Thies R S, Webster N J, McClain D A
Abstract excerpt
To study the mechanism and role of ligand-dependent endocytosis, we have engineered a mutant insulin receptor that retains its insulin binding and insulin-stimulated tyrosine kinase activities but does not exhibit ligand-induced internalization. The mutant has a deletion of the 16th exon which en...
Topics
- Base Sequence
- Cell Line
- Chromosome Deletion
- Down-Regulation
- Endocytosis
- Fibroblasts
- Humans
- Insulin
- Kinetics
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptor, Insulin
- Transfection