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Article

Transmembrane domain interactions are necessary for negative cooperativity of the insulin receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1994

Whittaker J, Garcia P, Yu G Q, Mynarcik D C

Abstract excerpt

Insulin binding to the human insulin receptor (HIR) is characterized by negatively cooperative site-site interactions that give rise to a curvilinear Scatchard plot. Insulin binding to recombinant secreted HIRs is linear, suggesting that interactions between the transmembrane or cytoplasmic domains of the receptor heterodimers may be responsible for the generation of negative cooperativity. To determine the...

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Identifiers

PMID: 7877620
DOI: 10.1210/mend.8.11.7877620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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