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Article

Transmembrane domain interactions are necessary for negative cooperativity of the insulin receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1994

Whittaker J, Garcia P, Yu G Q, Mynarcik D C

Abstract excerpt

Insulin binding to the human insulin receptor (HIR) is characterized by negatively cooperative site-site interactions that give rise to a curvilinear Scatchard plot. Insulin binding to recombinant secreted HIRs is linear, suggesting that interactions between the transmembrane or cytoplasmic domai...

Topics

Allosteric Regulation
Allosteric Site
Animals
Base Sequence
Cell Line
Cell Membrane
Cytoplasm
DNA, Complementary
Humans
Insulin
Mutation
Protein Binding
Receptor, Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Deletion

Transfection

Source

Identifiers

PMID: 7877620
DOI: 10.1210/mend.8.11.7877620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7877620-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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