Article
Postbinding characterization of five naturally occurring mutations in the human insulin receptor gene: impaired insulin-stimulated c-jun expression and thymidine incorporation despite normal receptor autophosphorylation.
Biochemistry - 20 Oct 1992
Quon M J, Cama A, Taylor S I
Abstract excerpt
Some patients with extreme insulin resistance have mutations in their insulin receptor gene. We previously identified five such mutations located in the extracellular domain of the insulin receptor (Asn-->Lys15, His-->Arg209, Phe-->Val382, Lys-->Glu460, and Asn-->Ser462) and studied the effects o...
Topics
- Cell Line
- DNA
- Deoxyglucose
- Fibroblasts
- Gene Expression
- Genes, jun
- Humans
- Insulin
- Insulin Resistance
- Kinetics
- Mutation
- Phosphorylation
- Receptor, Insulin
- Signal Transduction
- Thymidine
- Transfection