Structural basis by which a recessive mutation in the alpha-subunit of the insulin receptor affects insulin binding.

Article

Structural basis by which a recessive mutation in the alpha-subunit of the insulin receptor affects insulin binding.

The Journal of biological chemistry - 27 May 1994

Taouis M, Levy-Toledano R, Roach P, Taylor S I, Gorden P

Abstract excerpt

Recently, a mutation substituting Leu for Ser323 in the alpha-subunit of the human insulin receptor has been identified in an insulin-resistant patient. The Leu323 mutation leads to a severe impairment in insulin binding without significantly altering the processing or cell surface expression of...

Topics

3T3 Cells
Animals
Genes, Recessive
Insulin
Insulin Receptor Substrate Proteins
Leucine
Mice
Mutation
Phosphoproteins
Phosphorylation
Receptor, Insulin
Serine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.