Article
Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain.
The Journal of biological chemistry - 5 Jan 1992
Accili D, Kadowaki T, Kadowaki H, Mosthaf L, Ullrich A, Taylor S I
Abstract excerpt
Cell-surface proteins are transported through the endoplasmic reticulum and Golgi apparatus en route to the plasma membrane. Previously, we have identified three point mutations in the insulin receptor gene that impair transport of the mutant receptors to the cell surface: Asn15----Lys, His209----Arg, and Phe382----Val. Furthermore, these mutations impair post-translational processing steps that normally occur as...
Topics
- 3T3 Cells
- Animals
- Carrier Proteins
- Endoplasmic Reticulum
- Endoplasmic Reticulum Chaperone BiP
- Golgi Apparatus
- Heat-Shock Proteins
- Immunoglobulin Heavy Chains
- Mice
- Molecular Chaperones