Article
Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region.
The Journal of cell biology - 1 Dec 1991
Backer J M, Shoelson S E, Haring E, White M F
Abstract excerpt
The effect of receptor occupancy on insulin receptor endocytosis was examined in CHO cells expressing normal human insulin receptors (CHO/IR), autophosphorylation- and internalization-deficient receptors (CHO/IRA1018), and receptors which undergo autophosphorylation but lack a sequence required f...
Topics
- Animals
- CHO Cells
- Cell Membrane
- Coated Pits, Cell-Membrane
- Cricetinae
- Endocytosis
- Humans
- Insulin
- Insulin-Like Growth Factor I
- Insulin-Like Growth Factor II
- Kinetics
- Mutation
- Phosphorylation
- Receptor, Insulin