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Article

Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.

Journal of applied physiology (Bethesda, Md. : 1985) - 15 Mar 2013

Jayaram Bhavaani, Pan Weihong, Wang Yuping, Hsuchou Hung, Mace Aurelien, Cornelissen-Guillaume Germaine G, Mishra Pramod K, Koza Robert A, Kastin Abba J

Abstract excerpt

To determine how astrocytic leptin signaling regulates the physiological response of mice to diet-induced obesity (DIO), we performed metabolic analyses and hypothalamic leptin signaling assays on astrocytic leptin-receptor knockout (ALKO) mice in which astrocytes lack functional leptin receptor (ObR) signaling. ALKO mice and wild-type (WT) littermate controls were studied at different stages of DIO with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23329815
DOI: 10.1152/japplphysiol.01499.2012
PMCID: PMC3615600

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UCP1

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