Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Obesity induces functional astrocytic leptin receptors in hypothalamus.

Brain : a journal of neurology - 1 Apr 2009

Hsuchou Hung, He Yi, Kastin Abba J, Tu Hong, Markadakis Emily N, Rogers Richard C, Fossier Paul B, Pan Weihong

Abstract excerpt

The possible role of astrocytes in the regulation of feeding has been overlooked. It is well-established that the endothelial cells constituting the blood-brain barrier transport leptin from blood to brain and that hypothalamic neurons respond to leptin to induce anorexic signaling. However, few...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Calcium Signaling
Share to Diet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothalamus

Share to Leptin

Share to Obesity

Share to Receptors, Leptin

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 19293246
DOI: 10.1093/brain/awp029
PMCID: PMC2668946

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19293246-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obesity induces functional astrocytic leptin receptors in hypothalamus.PMID 19293246Read ↗

Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.Semantic proximity Read ↗

Dual role of striatal astrocytes in behavioral flexibility and metabolism in the context of obesitySemantic proximity Read ↗

Dual role of striatal astrocytes in behavioral flexibility and metabolism in the context of obesitySemantic proximity Read ↗

Fat food exacerbates post-prandial hypothalamic inflammation involving GFAP+ cells and microgliaSemantic proximity Read ↗

Long-Term Glucose Starvation Induces Inflammatory Responses and Phenotype Switch in Primary Cortical Rat Astrocytes.Semantic proximity Read ↗

Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth.Semantic proximity Read ↗

Circulating HDL levels control hypothalamic astrogliosis via apoA-I.Semantic proximity Read ↗

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control.Semantic proximity Read ↗

Effects of diet-induced obesity and voluntary exercise in a tauopathy mouse model: implications of persistent hyperleptinemia and enhanced astrocytic leptin receptor expression.Semantic proximity Read ↗

Selective deletion of leptin receptor in neurons leads to obesity.Semantic proximity Read ↗

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing NeuronsSemantic proximity Read ↗

Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.