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Article

Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2012

Pan Weihong, Hsuchou Hung, Cornelissen-Guillaume Germaine G, Jayaram Bhavvani, Wang Yuping, Tu Hong, Halberg Franz, Wu Xiaojun, Chua Streamson C, Kastin Abba J

Abstract excerpt

Leptin, a polypeptide hormone produced mainly by adipocytes, has diverse effects in both the brain and peripheral organs, including suppression of feeding. Other than mediating leptin transport across the blood-brain barrier, the role of the endothelial leptin receptor remains unclear. We recently generated a mutant mouse strain lacking endothelial leptin receptor signaling, and showed that there is an increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22323652
DOI: 10.1152/japplphysiol.00590.2011
PMCID: PMC3331584

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